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Want To Stress Less? These 13 Science-Backed Supplements Can Help*
Stress, like so many things in life, is best in moderation. In small doses, it's a positive force that prepares our bodies to spring into action, but repeated exposure can leave us feeling drained.
"It's not a good output for your body or your brain if you have high levels of stress all the time," Wendy Suzuki, Ph.D., a brain plasticity researcher and professor of neural science at New York University, tells mbg.
Along with stress-relieving practices like exercise and meditation, supplements can help bring your body back to baseline and relieve stress before it builds up into a problem.*
In a society that has, as Suzuki puts it, "co-opted our stress response" with constant external stimulation, these are the 14 best science-backed supplements to keep around for calm:*
mbg's picks for the best stress supplements:
How we chose
Ingredients
Our team ensures that each of these products is thoughtfully formulated from the active ingredients to those "Other ingredient" excipients, too. We are highly preferential towards clean formulas that are plant-centric (and oftentimes vegan or vegetarian) as well as free of GMOs, gluten, soy, dairy, major food allergens, high-fructose corn syrup, artificial sweeteners, synthetic dyes, and more.
Quality
We included stress supplements that prioritize quality. This includes robust manufaturing practices and comprehensive purity and potency testing. This helps ensure that impurities are absent or kept to a minimum (trace levels intrinsic to the environment, for example) and that active ingredients are included at the doses they state on the label.
Format
If you're taking a stress supplement daily, you'll want to make sure it's easy to work into your routine. For this reason, we feature a variety of different supplement formats, from capsules and tablets to powders and gummies.
Vetting
Our expert-vetted dietary supplement product selections and recommendations in the supplement space elevate quality, efficacy, innovation, and safety.
mbg's picks for the best stress supplements:
Best hemp gummies: Cornbread Hemp Full Spectrum CBD Gummies
Pros
- USDA certified organic
- Flower-only full-spectrum hemp extract
- Clean gummy formula
- Two CBD strengths available
Cons
- Contains 4 grams of sugar
- Trace levels of THC (if that’s not your thing)
Dietary:
Gluten-freeNon-GMODairy-freeVeganForm:
GummyDose:
1 gummyIf you're looking for a palatable but powerful treat, these tasty gummies from Kentucky-based company Cornbread Hemp contain 20 mg of USDA organic hemp-derived CBD per serving (two gummies). Unlike many gummies on the market, they're free of high-fructose corn syrup, gelatin, and artificial colors. They're also vegan (made from apple pectin) and sweetened with organic tapioca syrup and organic cane sugar. "The natural berry flavors are made from USDA organic blueberries, raspberries, and strawberries, while the color comes from organic beetroot," mbg's Ferira says of what makes them a cut above the rest. "That's one clean gummy."
Best CBD tincture: Fab CBD Oil
Pros
- Combats stress
- Variety of flavors and strengths
- Organically grown U.S. hemp
Cons
- Contains tree nut allergen (coconut)
Dietary:
Non-GMOOrganically grownForm:
TinctureDose:
1/2 dropperHemp-derived CBD helps ease stress due to the way it interacts with the body's endocannabinoid system (ECS). Though there's still a lot we have yet to discover about this mysterious system, it seems to help regulate many body processes—including the stress response. The compounds in hemp plants interact with the ECS and its receptors in a healthy way, helping it do its job as a master regulatory system.* Full-spectrum blends that contain many different types of hemp plant compounds, like FAB's, seem to do this the best. We also appreciate that their tinctures come in a portfolio of different flavors and strengths, making it easy to customize your calming experience.*
Best ashwagandha: Nature Made Calm & Relax™ Veggie Capsules
Pros
- Supports stress relief, calm, and relaxation*
- High-potency dose of magnesium
- Mineral and adaptogen duo
Cons
- Not suitable for vegans
- Lower magnesium bioavailability (oxide form)
- Plastic packaging
Dietary:
Gluten-freeVegetarianForm:
CapsuleDose:
2 capsulesAshwagandha (Withania somnifera) is an herb with stress resilience, anti-inflammatory, and antioxidant properties. As an adaptogen, it interacts with the adrenal system to support the body's natural ability to rebound from stressors.* Research shows that ashwagandha root and leaf extracts can be an effective stress remedy in doses 125 mg or higher. Nature Made's capsules contain that 125 mg threshold, as well as 300 mg of magnesium to support muscle relaxation.*
Best high-potency rhodiola: Hum Big Chill
Pros
- Adrenal balance support*
- Supports a healthy stress response*
- Enhances calm and focus*
Cons
- Long list of “other ingredients”
- Single active ingredient
- Plastic packaging
Dietary:
Gluten-freeNon-GMODairy-freeSoy-freeVeganForm:
CapsuleDose:
1 capsuleRhodiola (Rhodiola rosea) is another adaptogen that can be used for stress management (in quantities of 100 mg or higher). Native to Europe and Asia, the root of this flowering plant is where the calming properties lie, and they've been shown to ease self-reported levels of stress, anger, and sadness when taken consistently. Hum packs 500 mg of rhodiola root extract into every vegan capsule.*
Best lavender: Nature's Way CalmAid Lavender
Pros
- Combats feelings of anxiousness, tension, and stress*
- English lavender oil
- Non-drowsy
Cons
- Contains soy allergen
- Not suitable for vegans
Dietary:
Gluten-freeDairy-freeForm:
SoftgelDose:
1 softgelKnown for its delightfully fresh scent, English lavender (Lavandula angustifolia) can also be incorporated into relaxing supplements. The herbal compound has relaxing properties and has been shown in research to help calm states of restlessness. Clinical trials show that the oil is most effective at doses higher than 80 mg.* This supplement from Nature's Way contains 80 mg of lavender oil and not much else, making it a simple, straightforward pick for daily stress defense.*
Best lemon balm: Life Extension Enhanced Stress Relief
Pros
- Promotes healthy sleep and relaxation*
- Enhances mood and attention*
- Standardized lemon balm bioactives
Cons
- Plastic packaging
- Not suitable for vegans
Dietary:
Gluten-freeNon-GMOVegetarianForm:
CapsuleDose:
1 tabletAnother calming botanical, lemon balm (Melissa officinalis) also has sedative properties, and you'll often find it steeped into sleepytime teas. At 600-mg doses, it's been shown to increase self-reported calmness and support memory. However, it tends to decrease alertness, so it's best taken before bed.* This blend from Life Extension combines lemon balm with L-theanine, a stress-relieving amino acid found in green tea, to double down on its benefits.*
Best high-dose L-theanine: Zuma Nutrition L-theanine
Pros
- Promotes healthy sleep and cognitive function*
- Supports stress management and relaxation*
Cons
- Plastic packaging
Dietary:
Gluten-freeDairy-freeVeganForm:
CapsuleDose:
1 capsuleThis next supplement doubles down on L-theanine, an amino acid that has been shown to promote alpha brain waves, the same relaxing waves that occur during meditation. Due to the way it seems to inhibit excitatory stimuli in the brain, research shows that L-theanine can help ease stress and promote healthy cognition when taken as a daily supplement.* It seems to work best when taken regularly, and Zuma recommends consuming one of their L-theanine capsules every four hours throughout the day to compensate for the extract's short half-life.*
Best GABA & L-theanine: Pure Encapsulations Emotional Wellness
Pros
- Promotes healthy cognitive function*
- Supports emotional and mental well-being*
Cons
- Serving size is 1to 3 capsules
- Plastic packaging
Dietary:
Gluten-freeNon-GMODairy-freeSoy-freeVeganVegetarianForm:
CapsuleDose:
1 capsuleAlong with passionflower, rhodiola, and other bioactives, Pure Encapsulation's Emotional Wellness blend stacks L-theanine with GABA—another amino acid that promotes mental calm and clarity by enhancing alpha waves. Our brains naturally produce GABA to calm down overexcited neurons, but you can find synthesized GABA in stress-easing and sleep-promoting supplements too. Research shows that the relaxant gets to work relieving stress within an hour.*
Best magnesium powder: MegaFood Relax + Calm Magnesium Powder
Pros
- Promotes a sense of calm and relaxation*
- Supports the nervous system, muscle, and heart health*
- Certified B Corporation
Cons
- Contains flavoring agents (albeit natural)
- Plastic packaging
Dietary:
Non-GMODairy-freeSoy-freeVegetarianCertified KosherForm:
PowderDose:
1 scoopIf you prefer to drink your way to calm, this powder contains three forms of magnesium (citrate, malate, and glycinate) to promote muscle relaxation and a sense of mental ease. While there's no clinical scientific consensus, 100 mg of magnesium or more is thought to have a calming benefit.* This powder contains 300 mg per scoop, and it'll give your glass of water a hit of slight sweetness thanks to its monk fruit extract.
Best pet bundle: Charlotte's Web Calming Pet Chews + Calming Human Gummies
Pros
- Supports relaxation and stress relief*
- Full-spectrum hemp extract
- U.S. grown hemp
Cons
- Gummies contain 3 grams of added sugar
- Plastic packaging
Dietary:
Gluten-freeForm:
GummyChewsDose:
Up to 4 chews2 gummiesWhy keep all that calm to yourself? This Charlotte's Web bundle contains full-spectrum hemp chewables for humans and dogs, so you and your four-legged friend can find your Zen together.* Ferira explains, "In this creative combo, the dog chew delivers 2.5 mg of plant-based phytocannabinoids per chicken-flavored chew, while the hemp gummy for the pet owner delivers 10 mg of cannabinoids per two lemon-lime-flavored gummies."
Best adaptogenic combination: MegaFood Stress Protect
Pros
- Adaptogenic herbal blend
- Promotes a healthy stress response*
- Sustainably packaged
Cons
- Not suitable for vegans
Dietary:
Gluten-freeNon-GMODairy-freeSoy-freeVegetarianKosherForm:
TabletDose:
2 tabletsThis botanical blend from MegaFood pairs ashwagandha with other adaptogenic herbs that have long been used for stress relief and mood support: rhodiola root, schisandra berries, astragalus root, and holy basil leaf.* Some of these plants also promote stamina and ease fatigue, making this a good formula for getting your day started on the right foot. (MegaFood notes that it can be taken any time, even on an empty stomach.)*
Best herbal blend for stress: Metagenics Serenagen®
Pros
- Herbal blend to promote stress relief*
- Sustainable packaging
Cons
- Proprietary blend makes doses unknown
- MCT source unclear
Dietary:
Gluten-freeNon-GMOVegetarianForm:
TabletDose:
2 tabletsAnother herbal formula, this one gets its inspiration from traditional Chinese medicine. It combines quite the laundry list of plants and herbals that have calming properties (jujube and Asian ginseng, to name a couple) to help promote a steadier, more serene mood in the face of outside stressors. In traditional medicine, similar blends have also been used to support a healthy heart.*
Best for adrenal support: Designs for Health Adrenal Complex™
Pros
- Supports overall adrenal function*
- Promotes healthy cortisol balance*
- Bioactive B vitamins
Cons
- Not suitable for vegans
Dietary:
Gluten-freeNon-GMODairy-freeSoy-freeVegetarianForm:
CapsuleDose:
2 capsulesFinally, these vegetarian capsules contain an array of water-soluble micronutrients like vitamin C and B vitamins, along with targeted bioactives like PABA and N-acetyl-L-tyrosine that can support a healthy adrenal system and help keep stress hormones like cortisol in check.*
Frequently Asked Questions
How often do I need to take a supplement to feel any difference?
While it depends on the supplement, most of the products on this list can be consumed daily or on an as-needed basis.
Whether you take them before a particularly stressful call or during your nightly calming routine, you should be able to feel their calming effects.*
What dose should I take?
Again, it depends on the supplement, its ingredients, and your individual makeup. With stress-less supplements, more isn't always better, as high doses can lead to fatigue in some people.
Play around within the recommended range until you find a dose that's right for your stress needs, and then stick to it.* Ferira adds, "If relevant to your situation, partner with your health care provider to personalize your goals and pivot strategies as needed."
What should I look for in a stress supplement?
The best supplements always start with ingredients that have been scientifically vetted and studied in humans.
These vitamins, minerals, herbal botanicals, amino acids, and other bioactives should be present at doses high enough to be efficacious according to clinical science. Ferira always recommends watching out for "sprinkling"—or inadequate doses—in supplement products.
Traceability is also key. You'll want to ensure that the brand clearly identifies what its ingredients are and where they come from.
With botanical products, a good rule of thumb is to make sure the botanical name (genus and species) and parts of a plant (i.e., root, leaf, aerial parts, etc.) are specified on the label.
These active ingredients should make up most of the supplement. Avoid fillers like artificial colors and flavors, high-fructose corn syrup, etc., to ensure you're getting a high-quality product.
Are there any side effects I should know about?
The most common side effect of stress supplements is usually fatigue, and digestive upset is always possible (but uncommon) when you're taking something new.
As always, talk to your doctor beforehand to ensure the supplement won't interfere with any of your other medications.
And if stress starts to hinder your quality of life at any point, it's best to seek professional support. While these supplements can help ease occasional stress, they are not a treatment for clinical mood disorders or any medical condition.*
Do stress supplements actually work?
While supplements can’t get rid of stressors (wouldn’t that be nice!), thoughtfully formulated supplements can help us manage our resilience towards them. Certain botanicals like the hemp oil, ashwagandha extract, and lavender oil in calm+, have been clinically shown to improve stress resilience, elicit relaxation, and balance mood.* Whether it’s hemp oil supporting our intrinsic endocannabinoid system, or an adaptogenic herb like ashwagandha nurturing a more resilient response to stressors, supplements with science-backed ingredients can help us stress less.*
How long until I start to feel results?
Everyone’s different and every formulation is unique. With mbg’s calm+, most people will feel a calm, relaxing sensation shortly (e.g., within minutes to an hour) after taking calm+.*
The takeaway
There are a handful of ingredients that have been shown to relieve occasional stress and promote calm in clinical trials.* When integrated into a healthy stress management routine, they should help you approach life's daily challenges with a bit more ease.*
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